Rookie linemen Eric Wood and Andy Levitre did not start with the first unit to open the first organized team activity practice. The starting offensive line was, left to right, Langston Walker, Kirk Chambers, Geoff Hangartner, Seth McKinney and Brad Butler. Derek Fine and Derek Schouman started in a two-tight end set. However, Wood and Levitre both were mixed in with the first-teamers for several snaps during each portion of the practice. Gibran Hamdan, not free agent signee Ryan Fitzpatrick, served as quarterback for the second-team offense. The second-team tackles were Demetrius Bell on the left and Chris Denman on the right. The second-team center was Brandon Rodd.
On defense, Spencer Johnson took the place of Marcus Stroud at defensive tackle. Stroud watched from the sidelines. Aaron Schobel and Chris Kelsay started at ends. Kyle Williams was the other tackle. At linebacker was Kawika Mitchell, Paul Posluszny and Keith Ellison. At cornerback were Terrence McGee and Leodis McKelvin. At safety were Donte Whitner and Bryan Scott. Reggie Corner was the nickel cornerback. The second team defense included Copeland Bryan, John McCargo, Marcus Smith and Chris Ellis on the line (rookie Aaron Maybin got some snaps with the second teamers). It was Pat Thomas at middle linebacker with rookies Ashlee Palmer and Nic Harris on the outsides. In the secondary were Drayton Florence and Cary Harris (some of the time) at corner, with George Wilson and Ko Simpson at safety.
The Bills sprinkled some no-huddle mode into the offense throughout the 11 on 11 drills. The two best catches of the day were by Terrell Owens on a sideline bomb and by Stevie Johnson deep down the right sideline (from Hamdan). Lee Evans caught a deep left sideline throw from Edwards vs. McKelvin. McKelvin got a good jam on Owens one time to disrupt a pattern. Justin Jenkins also caught a long one from Fitzpatrick that went through the hands of rookie Ellis Lankster. But Lankster came back a little later and picked off an out-pattern throw by Hamdan intended for Roscoe Parrish. It was a pick-six touchdown play if it had been a live scrimmage.